Researchers at Rice University have discovered what may become the most effective way to fight acute myeloid leukemia.
Combining anti-cancer drugs that affect the cells’ mitochondria with a glycolytic inhibitor has shown to be highly adept at killing leukemia cells while leaving healthy cells intact, according to a recent open access paper published in Cell Death & Disease. In collaboration with The University of Texas MD Anderson Cancer Center, researchers at Rice University found that exposing leukemia cancer cell lines to low doses of mitocans combined with a glycolytic inhibitor killed a significant amount of cancer cells.
Advancements in Leukemia Treatment
The study showed a significant correlation between the cells’ ability to convert oxygen into ATP and their resistance to mitochondria-targeting cancer drugs. By combining them with ATP-producing glycolysis, the cocktail produces a synergistic effect: ATP production is blocked in the mitochondria, and mitocans are able to attack the cancer cells more effectively. The most successful test results showed that 86% of targeted leukemia cells were killed with the cocktail, suggesting new ways to individualize treatment for leukemia patients.